The Price Laboratory in the Department of Biomedical Engineering at the University of Virginia investigates the use of image-guided focused ultrasound for targeted drug and gene delivery. Specific projects entail using MRI-guided focused ultrasound to deliver gene- and drug-bearing nanoparticles across the blood-brain barrier to both treat brain tumors and reverse neurodegeneration in Parkinson’s disease. In a similar vein, we are also actively investigating how the thermal and mechanical effects created by certain regimes of focused ultrasound can be used to elicit anti-tumor immune responses against breast cancer and melanoma. Our research is highly collaborative. We work closely with UVa investigators in Radiology, the Human Immunotherapy Center, Neuro-oncology, and Cardiovascular Medicine, and we have a long-standing collaboration with investigators in the Johns Hopkins Center for Nanomedicine.